Vigabatrin

Evidence-based neurology checklist on vigabatrin: Mode of action Vigabatrin blocks GABA transferase Indications Dosing Ophthalmic side effects Neuropsychiatric side effects Systemic side effects Vigabatrin associated brain abnormalities (VABAM) Histological side effects Contraindications and…

Mode of action

  • Vigabatrin blocks GABA transferase

Indications

Dosing

Ophthalmic side effects

Neuropsychiatric side effects

Systemic side effects

Vigabatrin associated brain abnormalities (VABAM)

Histological side effects

Contraindications and precautions

References

  1. Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415. 
  2. Koul R, Chacko A, Ganesh A, Bulusu S, Al Riyami K. Vigabatrin associated retinal dysfunction in children with epilepsy. Arch Dis Child 2001; 85:469-473.
  3. Iannetti P, Spalice A, Perla FM, Conicella E, Raucci U, Bizzarri B. Visual field constriction in children with epilepsy on vigabatrin treatment. Pediatrics 2000; 106:838-842.
  4. Lahat E, Ben-Zeev B, Zlotnik J, Sela BA. Aminoaciduria resulting from vigabatrin administration in children with epilepsy. Pediatr Neurol 1999; 21:460-463.
  5. Gherpelli JL, Guerreiro MM, da Costa JC, et al. Vigabatrin in refractory childhood epilepsy. The Brazilian Multicenter Study. Epilepsy Res 1997; 29:1-6.
  6. And 11 more. Subscribe to see the full list

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