Felbamate

Evidence-based neurology checklist on felbamate: Mode of action Felbamate inhibits GABA receptor binding It may prevent generalisation of seizures by raising the seizure threshold Indications Dosing Serious side effects Neuropsychiatric side effects Urinary side effects Systemic side effects…

Mode of action

  • Felbamate inhibits GABA receptor binding
  • It may prevent generalisation of seizures by raising the seizure threshold

Indications

Dosing

Serious side effects

Neuropsychiatric side effects

Urinary side effects

Systemic side effects

Intermittent monitoring indices

References

  1. Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415. 
  2. Anon. Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome). The Felbamate Study Group in Lennox-Gastaut Syndrome. N Engl J Med 1993; 328:29-33.
  3. Zupanc ML, Roell Werner R, et al. Efficacy of felbamate in the treatment of intractable pediatric epilepsy. Pediatr Neurol 2010; 42:396-403. 
  4. Leppik IE, Dreifuss FE, Pledger GW, et al. Felbamate for partial seizures: results of a controlled clinical trial. Neurology 1991; 41:1785-1789.
  5. Shi LL, Dong J, Ni H, Geng J, Wu T. Felbamate as an add-on therapy for refractory epilepsy. Cochrane Database Syst Rev 2014; 7:CD008295. 
  6. And 6 more. Subscribe to see the full list

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