Stiripentol

Evidence-based neurology checklist on stiripentol: Mode of action Stiripentol is a GABAA receptor modulator It increases the serum levels of Clobazam and Valproate Indications Dosing Neuropsychiatric side effects Systemic side effects

Mode of action

  • Stiripentol is a GABAA receptor modulator
  • It increases the serum levels of Clobazam and Valproate

Indications

Dosing

Neuropsychiatric side effects

Systemic side effects

References

  1. Wirrell EC, Laux L, Franz DN, et al. Stiripentol in Dravet syndrome: results of a retrospective U.S. study. Epilepsia 2013; 54:1595-1604. 
  2. Jogamoto T, Yamamoto Y, Fukuda M, et al. Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy. Epilepsy Res 2016; 130:7-12. 
  3. Inoue Y, Ohtsuka Y; STP-1 Study Group. Long-term safety and efficacy of stiripentol for the treatment of Dravet syndrome: A multicenter, open-label study in Japan. Epilepsy Res 2015; 113:90-97. 
  4. Trivisano M, Specchio N, Vigevano F. Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. Eur J Paediatr Neurol 2015; 19:248-250. 
  5. Strzelczyk A, Kortland LM, Knake S, Rosenow F. Stiripentol for the treatment of super-refractory status epilepticus. Acta Neurol Scand 2015; 132:435-439.

Related checklists

Loading...