Sulthiame

Evidence-based neurology checklist on sulthiame: Mode of action Sulthiame is a sulphonamide It is a central carbonic anhydrase inhibitor It also blocks sodium channels Indications (adjunctive) Dosing Drugs whose blood levels are increased by Sulthiame Neurological side effects Systemic side effects

Mode of action

  • Sulthiame is a sulphonamide
  • It is a central carbonic anhydrase inhibitor
  • It also blocks sodium channels

Indications (adjunctive)

Dosing

Drugs whose blood levels are increased by Sulthiame

Neurological side effects

Systemic side effects

References

  1. Fejerman N, Caraballo R, Cersósimo R, Ferraro SM, Galicchio S, Amartino H. Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). Epilepsia 2012; 53:1156-1161. 
  2. Gorman KM, Shahwan A. Sultiame revisited: treatment of refractory absence seizures. Epileptic Disord 2016; 18:329-333. 
  3. Milburn-McNulty P, Powell G, Sills GJ, Marson AG. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev 2015; 10:CD009472. 
  4. Debus OM, Kurlemann G; Study group. Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication. Epilepsia 2004; 45:103-108.
  5. Debus OM, Köhring J, Fiedler B, Franssen M, Kurlemann G. Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study. Seizure 2002; 11:381-383.
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