Perampanel

Evidence-based neurology checklist on perampanel: Mode of action Perampanel is a post-synaptic AMPA receptor antagonist It enhances the glutamate pathway It decreases excitatory synaptic transmission Indications (adjunctive) Dosing Psychiatric side effects (mild) Neurological side effects Systemic…

Mode of action

  • Perampanel is a post-synaptic AMPA receptor antagonist
  • It enhances the glutamate pathway
  • It decreases excitatory synaptic transmission

Indications (adjunctive)

Dosing

Psychiatric side effects (mild)

Neurological side effects

Systemic side effects

Precautions

References

  1. Schulze-Bonhage A, Hintz M. Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability. Patient Prefer Adherence 2015; 9:1143-1151. 
  2. Ledingham DR, Patsalos PN. Perampanel: what is its place in the management of partial onset epilepsy? Neurol Ther 2013; 2:13-24. 
  3. Besag FM, Patsalos PN. Clinical efficacy of perampanel for partial-onset and primary generalized tonic-clonic seizures. Neuropsychiatr Dis Treat 2016; 12:1215-1220. 
  4. Greenwood J, Valdes J. Perampanel (fycompa): a review of clinical efficacy and safety in epilepsy. P T 2016; 41:683-698.
  5. Cada DJ, Levien TL, Baker DE. Perampanel. Hosp Pharm 2013; 48:321-331. 
  6. And 3 more. Subscribe to see the full list

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