Topiramate

Evidence-based neurology checklist on topiramate: Mechanism of action Topiramate blocks voltage gated sodium channels It augments GABAA receptors It inhibits carbonic anhydrase Dosing Indications Contraindications and precautions Neuropsychiatric side effects Systemic side effects Teratogenicity

Mechanism of action

  • Topiramate blocks voltage gated sodium channels
  • It augments GABAA receptors
  • It inhibits carbonic anhydrase

Dosing

Indications

Contraindications and precautions

Neuropsychiatric side effects

Systemic side effects

Teratogenicity

References

  1. Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415. 
  2. Faught E. Topiramate in the treatment of partial and generalized epilepsy. Neuropsychiatr Dis Treat 2007; 3:811-821.
  3. Arroyo S, Dodson WE, Privitera MD, et al; EPMN-106/INT-28 Investigators. Randomized dose-controlled study of topiramate as first-line therapy in epilepsy. Acta Neurol Scand 2005; 112:214-222.
  4. Sommer BR, Mitchell EL, Wroolie TE. Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity. Ther Adv Neurol Disord 2013; 6:211-227.
  5. Gopalakrishna M, Odayappan A, Srinivasan K, Rengaraj V. A case series of topiramate-induced angle closure crisis-an ophthalmic emergency. Cephalalgia 2020; 40:1389-1393.
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