Gabapentin

Evidence-based neurology checklist on gabapentin: Mode of action Gabapentin is a voltage-gated calcium channel modulator It increases brain GABA synthesis Indications Dosing Neurological side effects Genitourinary side effects Systemic side effects

Mode of action

  • Gabapentin is a voltage-gated calcium channel modulator
  • It increases brain GABA synthesis

Indications

Dosing

Neurological side effects

Genitourinary side effects

Systemic side effects

References

  1. Taylor CP. Mechanisms of action of gabapentin. Rev Neurol (Paris) 1997; 153(Suppl 1):S39-S45. 
  2. Taylor CP, Gee NS, Su TZ, et al. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998; 29:233-249.
  3. Al-Bachari S, Pulman J, Hutton JL, Marson AG. Gabapentin add-on for drug-resistant partial epilepsy. Cochrane Database Syst Rev 2013; 7:CD001415. 
  4. McLean MJ. Gabapentin in the management of convulsive disorders. Epilepsia 1999; 40(Suppl 6):S39-S50.
  5. Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
  6. And 10 more. Subscribe to see the full list

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