Pregabalin
Evidence-based neurology checklist on pregabalin: Mechanism of action Pregabalin is a derivative of GABA It has affinity for the α2-δ subunit of the voltage gated calcium channel subunit It increases the rate of GABA transport: but it does not bind GABA receptors Dosing Indication Movement…
Mechanism of action
- Pregabalin is a derivative of GABA
- It has affinity for the α2-δ subunit of the voltage gated calcium channel subunit
- It increases the rate of GABA transport: but it does not bind GABA receptors
Dosing
Indication
Movement disorders
Other neurological side effects
Psychiatric side effects
Genitourinary side effects
Systemic side effects
References
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T 2010; 35:392-415.
- Hamandi K, Sander JW. Pregabalin: a new antiepileptic drug for refractory epilepsy. Seizure 2006; 15:73-78.
- Brodie MJ. Pregabalin as adjunctive therapy for partial seizures. Epilepsia. 2004; 45(Suppl 6):19-27.
- Rissardo JP, Caprara ALF. Pregabalin-associated movement disorders: a literature review. Brain Circ 2020; 6:96-106.
- Arroyo S, Anhut H, Kugler AR, et al; Pregabalin 1008-011 International Study Group. Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures. Epilepsia 2004; 45:20-27.
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