Cenobamate

Evidence-based neurology checklist on cenobamate: Pharmacology Cenobamate inhibits voltage-gated sodium currents It is also a GABAA channel modulator Use Indication Dosing Contraindications Side effects Acronym

Pharmacology

  • Cenobamate inhibits voltage-gated sodium currents
  • It is also a GABAA channel modulator

Use

Indication

Dosing

Contraindications

Side effects

Acronym

References

  1. Keam SJ. Cenobamate: first approval. Drugs 2020; 80:73-78.
  2. Krauss GL, Klein P, Brandt C, et al. Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial. Lancet Neurol 2020; 19:38-48.
  3. Chung SS, French JA, Kowalski J, et al. Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures. Neurology 2020; 94:e2311-e2322. 
  4. Makridis KL, Kaindl AM. Real-world experience with cenobamate: A systematic review and meta-analysis. Seizure 2023; 112:1-10.
  5. Rosenfeld WE, Ferrari L, Kamin M. Efficacy of cenobamate by focal seizure subtypes: post-hoc analysis of a phase 3, multicenter, open-label study. Epilepsy Res 2022; 183:106940.
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