Multiple sclerosis (MS): systemic features

Evidence-based neurology checklist on multiple sclerosis (ms): systemic features: Respiratory dysfunction Excessive daytime sleepiness (EDS) Respiratory impairment: this is frequent in wheelchair-bound patients Neurogenic pulmonary oedema (NPE): this includes flash pulmonary oedema Cardiac…

Respiratory dysfunction

  • Excessive daytime sleepiness (EDS)
  • Respiratory impairment: this is frequent in wheelchair-bound patients
  • Neurogenic pulmonary oedema (NPE): this includes flash pulmonary oedema

Cardiac dysfunction

Episodic hypothermia

Systemic lupus erythematosus (SLE)

Hormonal disorders

Gastrointestinal disorders

Possible cancer risk

Other reported systemic MS associations

References

  1. Li Y, Munger KL, Batool-Anwar S, de Vito K, Ascherio A, Gao X. Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. Neurology 2012; 78:1500-1506.
  2. Levy J, Bensmail D, Brotier-Chomienne A, Butel S, Joussain C, Hugeron C, Prigent H. Respiratory impairment in multiple sclerosis: a study of respiratory function in wheelchair-bound patients. Eur J Neurol 2017; 24:497-502.  
  3. Valencia-Sanchez C, Goodman BP, Carter JL, Wingerchuk DM. The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations. Mult Scler 2019; 25:758-765.
  4. Plummer C, Campagnaro R. Flash pulmonary edema in multiple sclerosis. J Emerg Med 2013; 44:e169-e172.  
  5. Androdias G, Bernard E, Biotti D, et al. Multiple sclerosis broke my heart. Ann Neurol 2017; 81:754-758.
  6. And 24 more. Subscribe to see the full list

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