Multiple sclerosis (MS): smouldering associated worsening

Evidence-based neurology checklist on multiple sclerosis (ms): smouldering associated worsening: Pathology Acute inflammation Neurodegeneration Clinical manifestations Radiological markers Other forms of MS worsening Treatment Acronyms

Pathology

  • Acute inflammation
  • Neurodegeneration

Clinical manifestations

Radiological markers

Other forms of MS worsening

Treatment

Acronyms

References

  1. Scalfari A, Traboulsee A, Oh J, et al. Smouldering-associated worsening in multiple sclerosis: an international consensus statement on definition, biology, clinical implications, and future directions. Ann Neurol 2024; 96:826-845.
  2. Niedziela N, Kalinowska A, Kułakowska A, et al. Clinical and therapeutic challenges of smouldering multiple sclerosis. Neurol Neurochir Pol 2024; 58:245-255.
  3. Giovannoni G, Hawkes CH, Lechner-Scott J, Levy M, Yeh EA. Smouldering-associated worsening or SAW: the next therapeutic challenge in managing multiple sclerosis. Mult Scler Relat Disord 2024; 92:106194.

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