Multiple sclerosis (MS): non-modifiable risk factors
Evidence-based neurology checklist on multiple sclerosis (ms): non-modifiable risk factors: Genetic risk factors TYK2 CYP27B1 NLRP1 IL-7Ra: interleukin 7 receptor α chain TNFAIP3 TNFRSF1A STK11: serine therorine kinase 11 IL18: iinterleukin 18 JGB1 HLA-DRB1*1501 variant Ethnicity Age-related risk…
Genetic risk factors
- TYK2
- CYP27B1
- NLRP1
- IL-7Ra: interleukin 7 receptor α chain
- TNFAIP3
- TNFRSF1A
- STK11: serine therorine kinase 11
- IL18: iinterleukin 18
- JGB1
- HLA-DRB1*1501 variant
Ethnicity
Age-related risk factors
Month of birth
Chronic cerebrospinal venous insufficiency (CCVI)
References
- Ramagopalan SV, Dobson R, Meier UC, Giovannoni G. Multiple sclerosis: risk factors, prodromes, and potential causal pathways. Lancet Neurol 2010; 9:727–739.
- Dyment DA, Cader MZ, Chao MJ, et al. Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene. Neurology 2012; 79:406-411.
- Ban M, Goris A, Lorentzen AR, et al. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet 2009; 17:1309-1313.
- Mero IL, Lorentzen AR, Ban M, et al. A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. Eur J Hum Genet 2010; 18:502-504.
- Ramagopalan SV, Dyment DA, Cader MZ, et al. Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 2011; 70:881-886.
- And 17 more. Subscribe to see the full list
Related checklists
- Multiple sclerosis (MS): classification
- Multiple sclerosis (MS): revised McDonald diagnostic criteria
- Multiple sclerosis (MS): modifiable risk factors
- Multiple sclerosis (MS): protective factors
- Multiple sclerosis (MS): typical neurological features
- Multiple sclerosis (MS): other neurological features
- Multiple sclerosis (MS): systemic features
- Multiple sclerosis (MS): paroxysmal attacks
- Multiple sclerosis (MS): seizures
- Multiple sclerosis (MS): differential diagnosis
- Multiple sclerosis (MS): clinical red flags against diagnosis
- Multiple sclerosis (MS): laboratory red flags against diagnosis
- Multiple sclerosis (MS): poor prognostic factors
- Multiple sclerosis (MS): smouldering associated worsening
