Multiple sclerosis (MS): modifiable risk factors

Evidence-based neurology checklist on multiple sclerosis (ms): modifiable risk factors: Dietary Low vitamin D: individual, maternal, and neonatal Low polyunsaturated fatty acids Low fish consumption Cigarette smoking Traumatic brain injury (TBI) Lifestyle Infections Environmental Other risk…

Dietary

  • Low vitamin D: individual, maternal, and neonatal
  • Low polyunsaturated fatty acids
  • Low fish consumption

Cigarette smoking

Traumatic brain injury (TBI)

Lifestyle

Infections

Environmental

Other risk factors

Non-risk factors

References

  1. Simpson S Jr, der Mei IV, Taylor B. The role of vitamin D in multiple sclerosis: biology & biochemistry, epidemiology and potential roles in treatment. Med Chem 2017; (Epub ahead of print).
  2. Hartl C, Obermeier V, Gerdes LA, Brügel M, von Kries R, Kümpfel T. Seasonal variations of 25-OH vitamin D serum levels are associated with clinical disease activity in multiple sclerosis patients. J Neurol Sci 2017; 375:160-164.
  3. Dickinson JL, Perera DI, van der Mei AF, et al. Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 vitamin D receptor variant in this interaction. Mult Scler 2009; 15:563-570.
  4. Rhead B, Bäärnhielm M, Gianfrancesco M, et al. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurol Genet 2016; 2:e97. 
  5. Munger KL, Åivo J, Hongell K, Soilu-Hänninen M, Surcel HM, Ascherio A. Vitamin D status during pregnancy and risk of multiple sclerosis in offspring of women in the Finnish maternity cohort. JAMA Neurol 2016; 73:515-519. 
  6. And 41 more. Subscribe to see the full list

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