Multiple sclerosis (MS): seizures

Evidence-based neurology checklist on multiple sclerosis (ms): seizures: Epidemiology of seizures in MS Seizures occur in about 2-8% of people with MS The risk correlates with disease severity The risk is also higher in those on SP1R modulating drugs Risk factors Seizure focus in MS Presentation…

Epidemiology of seizures in MS

  • Seizures occur in about 2-8% of people with MS
  • The risk correlates with disease severity
  • The risk is also higher in those on SP1R modulating drugs

Risk factors

Seizure focus in MS

Presentation of seizures in MS

References

  1. Sponsler JL, Kendrick-Adey AC. Seizures as a manifestation of multiple sclerosis. Epileptic Disord 2011; 13:401-410.
  2. Shaygannejad V, Ashtari F, Zare M, Ghasemi M, Norouzi R, Maghzi H. Seizure characteristics in multiple sclerosis patients. J Res Med Sci 2013; 18(Suppl 1):S74-S77.
  3. Kavčič A, Hofmann WE. Unprovoked seizures in multiple sclerosis: why are they rare? Brain Behav 2017; 7:e00726. 
  4. Burman J, Zelano J. Epilepsy in multiple sclerosis: a nationwide population-based register study. Neurology 2017; 89:2462-2468. 
  5. Pozzilli V, Haggiag S, Di Filippo M, et al. Incidence and determinants of seizures in multiple sclerosis: a meta-analysis of randomised clinical trials. JNNP 2024; 95:612-619.
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