Multiple sclerosis (MS): poor prognostic factors
Evidence-based neurology checklist on multiple sclerosis (ms): poor prognostic factors: Genetic factors LLRP2 variant MBP variant ApoE4 variant Lifestyle factors Late-onset relapsing remitting MS (LORRMS) Other comorbid factors Environmental factors Radiological factors Serum factors Cerebrospinal…
Genetic factors
- LLRP2 variant
- MBP variant
- ApoE4 variant
Lifestyle factors
Late-onset relapsing remitting MS (LORRMS)
Other comorbid factors
Environmental factors
Radiological factors
Serum factors
Cerebrospinal fluid (CSF) factors
Optical coherence tomography (OCT) factors
Factors not associated with poor prognosis
Factors associated with better prognosis
References
- Hilven K, Vandebergh M, Smets I, Mallants K, Goris A, Dubois B. Genetic basis for relapse rate in multiple sclerosis: association with LRP2 genetic variation. Mult Scler 2018; 24:1773-1775.
- Zhou Y, Graves JS, Simpson S Jr, et al; Ausimmmune/AusLong investigators group. Genetic variation in the gene LRP2 increases relapse risk in multiple sclerosis. JNNP 2017; 88:864-868.
- Zhou Y, Simpson S Jr, Charlesworth JC, van der Mei I, Lucas RM, Ponsonby AL; AUSLONG Investigators Group, Taylor BV. Variation within MBP gene predicts disease course in multiple sclerosis. Brain Behav 2017; 7:e00670.
- Portaccio E, Aprea MG, De Meo E, et al. Relapse-associated worsening in apolipoprotein E ε4 carriers with relapsing multiple sclerosis. J Neurol Neurosurg Psychiatry 2026; 97:774-779.
- Hempel S, Graham GD, Fu N, et al. A systematic review of the effects of modifiable risk factor interventions on the progression of multiple sclerosis. Mult Scler 2017; 23:513-524.
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Related checklists
- Multiple sclerosis (MS): classification
- Multiple sclerosis (MS): revised McDonald diagnostic criteria
- Multiple sclerosis (MS): non-modifiable risk factors
- Multiple sclerosis (MS): modifiable risk factors
- Multiple sclerosis (MS): protective factors
- Multiple sclerosis (MS): typical neurological features
- Multiple sclerosis (MS): other neurological features
- Multiple sclerosis (MS): systemic features
- Multiple sclerosis (MS): paroxysmal attacks
- Multiple sclerosis (MS): seizures
- Multiple sclerosis (MS): differential diagnosis
- Multiple sclerosis (MS): clinical red flags against diagnosis
- Multiple sclerosis (MS): laboratory red flags against diagnosis
- Multiple sclerosis (MS): smouldering associated worsening
