Neuromyelitis optica spectrum disorder (NMOSD): prognostic factors

Evidence-based neurology checklist on neuromyelitis optica spectrum disorder (nmosd): prognostic factors: Poor prognostic features Younger onset age African ancestry Late onset NMOSD (LO-NMOSD): onset age ≥60 years Women >40 years Aquaporin4 (AQP4) antibody status Potential prognostic biomarkers

Poor prognostic features

  • Younger onset age
  • African ancestry
  • Late onset NMOSD (LO-NMOSD): onset age ≥60 years
  • Women >40 years
  • Aquaporin4 (AQP4) antibody status

Potential prognostic biomarkers

References

  1. Sepúlveda M, Armangué T, Sola-Valls N, et al. Neuromyelitis optica spectrum disorders: comparison according to the phenotype and serostatus. Neurol Neuroimmunol Neuroinflamm 2016; 3:e225.
  2. Mealy MA, Kessler RA, Rimler Z, et al. Mortality in neuromyelitis optica is strongly associated with African ancestry. Neurol Neuroimmunol Neuroinflamm 2018; 5:e468.
  3. Pu YL, Feng JZ, Meng HX, et al. Myelitis-predominant aggressive phenotype: unveiling unique patterns of late-onset neuromyelitis optica spectrum disorders. Ann Neurol 2026; 99:1139-1151.
  4. Borisow N, Kleiter I, Gahlen A, et al; NEMOS (Neuromyelitis Optica Study Group). Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Mult Scler 2017; 23:1092-1103.
  5. Stellmann JP, Krumbholz M, Friede T, et al; NEMOS (Neuromyelitis Optica Study Group). Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response. JNNP 2017; 88:639-647.
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