Neuromyelitis optica spectrum disorder (NMOSD): central neurological features

Evidence-based neurology checklist on neuromyelitis optica spectrum disorder (nmosd): central neurological features: Demographic features The mean onset age is 30 years It predominantly affects females in the fertile ages Females are more likely than men to be antibody positive The course is…

Demographic features

  • The mean onset age is 30 years
  • It predominantly affects females in the fertile ages
  • Females are more likely than men to be antibody positive
  • The course is relapsing in 80% of cases and monophasic in 20%
  • One case has been reported following Zika virus infection

Cranial nerve features

Cerebral features

Brainstem features

Spinal cord features

Spinal movement disorders (SMDs)

NMO relapses

Late onset NMO

Other rare NMO variants

Demographic features

Cranial nerve features

Cerebral features

Brainstem features

Spinal cord features

Spinal movement disorders (SMDs)

NMO relapses

Late onset NMO

Other rare NMO variants

References

  1. Dellavance A, Alvarenga RR, Rodrigues SH, Kok F, de Souza AW, Andrade LE. Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases. Eur J Neurol 2012; 19:248-252.
  2. Argyriou AA, Makris N. Neuromyelitis optica: a distinct demyelinating disease of the central nervous system. Acta Neurol Scand 2008; 128:209-217.
  3. Borisow N, Kleiter I, Gahlen A, et al; NEMOS (Neuromyelitis Optica Study Group). Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Mult Scler 2017; 23:1092-1103.
  4. Aspahan MC, Leonhard SE, Gomez RS, et al. Neuromyelitis optica spectrum disorder associated with Zika virus infection. Neurol Clin Pract 2019; 9:e1-e3.
  5. Oertel FC, Kuchling J, Zimmermann H, et al. Microstructural visual system changes in AQP4-antibody-seropositive NMOSD. Neurol Neuroimmunol Neuroinflamm 2017; 4:e334.
  6. And 55 more. Subscribe to see the full list

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