Hereditary spastic paraplegia type 29 (SPG29)

Evidence-based neurology checklist on hereditary spastic paraplegia type 29 (spg29): Genetics This is caused by mutations in chromosome 1p The transmission is autosomal dominant There is possible genetic anticipation The mean onset age is in the mid-teens Clinical features

Genetics

  • This is caused by mutations in chromosome 1p
  • The transmission is autosomal dominant
  • There is possible genetic anticipation
  • The mean onset age is in the mid-teens

Clinical features

References

  1. Orlacchio A, Kawarai T, Gaudiello F, St George-Hyslop PH, Floris R, Bernardi G. New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1. Ann Neurol 2005; 58:423-429. 

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