Hereditary spastic paraplegia type 27 (SPG27)

Evidence-based neurology checklist on hereditary spastic paraplegia type 27 (spg27): Genetics This is caused by mutations in chromosome 10q The transmission is autosomal recessive It is an early onset HSP Clinical features Investigations

Genetics

  • This is caused by mutations in chromosome 10q
  • The transmission is autosomal recessive
  • It is an early onset HSP

Clinical features

Investigations

References

  1. Ribai P, Stevanin G, Bouslam N, et al. A new phenotype linked to SPG27 and refinement of the critical region on chromosome. J Neurol 2006; 253:714-719. 
  2. Meijer IA, Cossette P, Roussel J, Benard M, Toupin S, Rouleau GA. A novel locus for pure recessive hereditary spastic paraplegia maps to 10q22.1-10q24.1. Ann Neurol 2004; 56:579-582. 

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