Chronic granulomatous herpes simplex encephalitis

Evidence-based neurology checklist on chronic granulomatous herpes simplex encephalitis: Demographic features and pathogenesis This usually occurs in children: but it may affect adults It is usually biphasic following the initial herpes infection It may be related to toll-like receptor 3 (TLR-3)…

Demographic features and pathogenesis

  • This usually occurs in children: but it may affect adults
  • It is usually biphasic following the initial herpes infection
  • It may be related to toll-like receptor 3 (TLR-3) deficiency

Clinical features

Pathological features

Differential diagnosis

Treatment

References

  1. Schutz PW, Fauth CT, Al-Rawahi GN, et al. Granulomatous herpes simplex encephalitis in an infant with multicystic encephalopathy: a distinct clinicopathologic entity? Pediatr Neurol 2014; 50:392-396.
  2. Varatharaj A, Nicoll JA, Pelosi E, Pinto AA. Corticosteroid-responsive focal granulomatous herpes simplex type-1 encephalitis in adults. Pract Neurol 2017; 17:140-144.
  3. Viñas JM, Gonzalez MJ, Ribes AG, Expósito RG, Bragado FG. Postencephalitic chronic granulomatous disease. Pediatr Neurol 2006; 35:297-299.
  4. Adamo MA, Abraham L, Pollack IF. Chronic granulomatous herpes encephalitis: a rare entity posing a diagnostic challenge. J Neurosurg Pediatr 2011; 8:402-406. 
  5. Hackney JR, Harrison DK, Rozzelle C, et al. Chronic granulomatous herpes encephalitis in a child with clinically intractable epilepsy. Case Rep Pediatr 2012; 2012:849812.

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