Temporal lobe epilepsy with amygdala enlargement (TLE-AE)

Evidence-based neurology checklist on temporal lobe epilepsy with amygdala enlargement (tle-ae): Clinical features Middle-age age onset Complex partial seizures Generalised seizures: these usually occur in sleep Anxiety and depression: these are present in >90% of cases Progressive memory…

Clinical features

  • Middle-age age onset
  • Complex partial seizures
  • Generalised seizures: these usually occur in sleep
  • Anxiety and depression: these are present in >90% of cases
  • Progressive memory impairment
  • Autoimmune antibodies

Magnetic resonance imaging (MRI) brain: features

Positron emission tomography (PET)

Electroencephalogram (EEG): features

Outcome

References

  1. Lv RJ, Sun ZR, Cui T, Guan HZ, Ren HT, Shao XQ. Temporal lobe epilepsy with amygdala enlargement: a subtype of temporal lobe epilepsy. BMC Neurol 2014; 14:194.
  2. Malter MP, Widman G, Galldiks N, et al. Suspected new-onset autoimmune temporal lobe epilepsy with amygdala enlargement. Epilepsia 2016; 57:1485-1494. 
  3. Mitsueda-Ono T, Ikeda A, Inouchi M, et al. Amygdalar enlargement in patients with temporal lobe epilepsy. JNNP 2011; 82:652-657.
  4. Minami N, Morino M, Uda T, et al. Surgery for amygdala enlargement with medial temporal lobe epilepsy: pathological findings and seizure control. JNNP 2015; 86:887-894.
  5. Takaya S, Ikeda A, Mitsueda-Ono T, et al. Temporal lobe epilepsy with amygdala enlargement: a morphologic and functional study. J Neuroimaging 2014; 24:54-62. 
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