MOGHE

Evidence-based neurology checklist on moghe: Genetics and pathology This is a drug-resistant epilepsy More than 70% have SLC35A2 gene mutations There is oligodendroglial cell proliferation in the white matter and deep cortex Epidemiological features Clinical phenotypes Clinical features…

Genetics and pathology

  • This is a drug-resistant epilepsy
  • More than 70% have SLC35A2 gene mutations
  • There is oligodendroglial cell proliferation in the white matter and deep cortex

Epidemiological features

Clinical phenotypes

Clinical features

Differential diagnosis

Electroencephalogram (EEG)

Magnetic resonance imaging (MRI) brain

Pathological features

Treatment

Eponym

Synonym

References

  1. Zhan Y, Chen S, Jin Z, et al. Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy: a systematic review. Neurol Genet 2025; 11:e200240.
  2. Liu X, Zhu Y, Liu Q, et al. Clinical characteristics and surgical outcomes in children with mild malformation of cortical development and oligodendroglial hyperplasia in epilepsy. Epilepsia Open 2023; 8:898-911.
  3. Bonduelle T, Hartlieb T, Baldassari S, et al. Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE). Acta Neuropathol Commun 2021; 9:3.
  4. Mendes Coelho VC, Morita-Sherman M, et al. Magnetic resonance imaging findings and clinical characteristics in mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy in a predominantly adult cohort. Epilepsia 2021; 62:1429-1441.
  5. Dimova PS, Metodiev D, Todorov T, et al. Clinical characteristics and multimodal imaging can help diagnosing and treating mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy. Epileptic Disord 2024; 26:662-675.
  6. And 1 more. Subscribe to see the full list

Related checklists

Loading...