Autosomal dominant epilepsy with auditory features (ADEAF)

Evidence-based neurology checklist on autosomal dominant epilepsy with auditory features (adeaf): Genetic mutations LGI1: this accounts for 50% of cases CNTNAP2 DEPDC5 SCN1A Seizure triggers Typical auditory symptoms Other clinical features Treatment Synonym

Genetic mutations

  • LGI1: this accounts for 50% of cases
  • CNTNAP2
  • DEPDC5
  • SCN1A

Seizure triggers

Typical auditory symptoms

Other clinical features

Treatment

Synonym

References

  1. Michelucci R, Poza JJ, Sofia V, et al. Autosomal dominant lateral temporal epilepsy: clinical spectrum, new epitempin mutations, and genetic heterogeneity in seven European families. Epilepsia 2003; 44:1289-1297.
  2. Crompton DE, Scheffer IE, Taylor I, et al. Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain 2010; 133:3221-3231.
  3. Vadlamudi L, Sceffer IE, Berkovic SF. Genetics of temporal lobe epilepsy. JNNP 2003; 74:1359-1361.
  4. Klein KM, Pendziwiat M, Cohen R, et al. Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia. J Neurol 2016; 263:11-16. 
  5. Pippucci T, Licchetta L, Baldassari S, et al. Epilepsy with auditory features: a heterogeneous clinico-molecular disease. Neurol Genet 2015; 1:e5.
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