PARK8 genetic Parkinson's disease (PD)

Evidence-based neurology checklist on park8 genetic parkinson's disease (pd): Genetics This is caused by mutations in the LRRK2 gene on chromosome 12q The transmission is autosomal dominant Aspirin and Ibuprofen may reduce the penetrance Lewy bodies are present in some cases Clinical features…

Genetics

  • This is caused by mutations in the LRRK2 gene on chromosome 12q
  • The transmission is autosomal dominant
  • Aspirin and Ibuprofen may reduce the penetrance
  • Lewy bodies are present in some cases

Clinical features

Treatment

References

  1. Wszolek ZK, Pfeiffer B, Fulgham JR, et al. Western Nebraska family (family D) with autosomal dominant parkinsonism. Neurology 1995; 45:502-505.
  2. Paisán-Ruíz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004; 44:595-600.
  3. San Luciano M, Tanner CM, Meng C, et al. Nonsteroidal anti-inflammatory use and LRRK2 Parkinson's disease penetrance. Mov Disord 2020 (Online ahead of print).

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