PARK21 genetic Parkinson's disease (PD)

Evidence-based neurology checklist on park21 genetic parkinson's disease (pd): Genetics This is probably caused by mutations of the TMEM230 or DNAJC13 genes These are on chromosome 3q The transmission is autosomal dominant Lewy bodies are present Clinical features Treatment

Genetics

  • This is probably caused by mutations of the TMEM230 or DNAJC13 genes
  • These are on chromosome 3q
  • The transmission is autosomal dominant
  • Lewy bodies are present

Clinical features

Treatment

References

  1. Deng HX, Shi Y, Yang Y, et al. Identification of TMEM230 mutations in familial Parkinson's disease. Nat Genet 2016; 48:733-739. 
  2. Vilariño-Güell C, Rajput A, Milnerwood AJ, et al. DNAJC13 mutations in Parkinson disease. Hum Mol Genet 2014; 23:1794-1801.

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