PARK4 genetic Parkinson's disease (PD)

Evidence-based neurology checklist on park4 genetic parkinson's disease (pd): Genetics This is caused by SNCA gene mutations or multiplication The gene is on chromosome 4q The transmission is autosomal dominant There are widespread Lewy bodies Neurological features Psychiatric features Treatment

Genetics

  • This is caused by SNCA gene mutations or multiplication
  • The gene is on chromosome 4q
  • The transmission is autosomal dominant
  • There are widespread Lewy bodies

Neurological features

Psychiatric features

Treatment

References

  1. Fuchs J, Nilsson C, Kachergus J, et al. Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology 2007; 68:916-922. 
  2. Farrer M, Kachergus J, Forno L, et al. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol 2004; 55:174-179.
  3. Muenter MD, Forno LS, Hornykiewicz O, et al. Hereditary form of parkinsonism-dementia. Ann Neurol 1998; 43:768-781.

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