Opioid leukoencephalopathy

Evidence-based neurology checklist on opioid leukoencephalopathy: Acute toxic leukoencephalopathy (ATL): features Amnesia Inattention Disorientation Seizures Tremors Dysautonomia Rigidity Fever Hyperthermia Tachycardia Hypertension Rhabdomyolysis Coma Delayed post-hypoxic leukoencephalopathy…

Acute toxic leukoencephalopathy (ATL): features

  • Amnesia
  • Inattention
  • Disorientation
  • Seizures
  • Tremors
  • Dysautonomia
  • Rigidity
  • Fever
  • Hyperthermia
  • Tachycardia
  • Hypertension
  • Rhabdomyolysis
  • Coma

Delayed post-hypoxic leukoencephalopathy (DPHL): features

Systemic features

References

  1. Winstanley EL, Mahoney JJ 3rd, Castillo F, Comer SD. Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: a systematic review. Drug Alcohol Depend 2021; 226:108838. 
  2. Knudsen GH, Kermanian N, Kock-Jensen CH, Antulov R. Opioid-induced leukoencephalopathies: a report of two cases. Case Rep Neurol 2022; 14:25-30.

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