Heroin spongiform leukoencephalopathy (HSLE)
Evidence-based neurology checklist on heroin spongiform leukoencephalopathy (hsle): Pathogenesis HSLE may follow a single heroin dose There is a possible genetic predisposition Clinical features Pathological features Magnetic resonance imaging (MRI) brain: features MRI brain lesion locations…
Pathogenesis
- HSLE may follow a single heroin dose
- There is a possible genetic predisposition
Clinical features
Pathological features
Magnetic resonance imaging (MRI) brain: features
MRI brain lesion locations
Magnetic resonance spectroscopy (MRS): features
References
- Tormoehlen LM. Toxic leukoencephalopathies. Psychiatr Clin North Am 2013; 36:277-292.
- Tormoehlen LM. Toxic leukoencephalopathies. Neurol Clin 2011; 29:591-605.
- Bach AG, Jordan B, Wegener NA, et al. Heroin spongiform leukoencephalopathy (HSLE). Clin Neuroradiol 2012; 22:345-349.
- Vella S, Kreis R, Lovblad KO, Steinlin M. Acute leukoencephalopathy after inhalation of a single dose of heroin. Neuropediatrics 2003; 34:100-104.
- Zhou L, Lu BX, Yin J. Association of cytochrome P4502D6 gene polymorphism with the susceptibility of heroin spongiform leucoencephalopathy. Nan Fang Yi Ke Da Xue Xue Bao 2010; 30:572-574.
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