Opioid-associated amnestic syndrome (OAS)

Pathology

• It is most frequently caused by Fentanyl
• It has also been reported with Hydromorphone

Demographic features

Diagnostic criteria

Magnetic resonance imaging (MRI) brain

Magnetic resonance spectroscopy (MRS) brain

Other investigations

Clinical differentials

Radiological differentials

References

1. Ciurylo W, Noh E. Opioid-associated amnestic syndrome. Cureus 2021; 13:e16714. 
2. Walker ML, Patel K, Li T, Kassir M. Opioid-associated amnestic syndrome. Cureus 2021; 13:e20056. 
3. Taylor RG, Budhram A, Lee DH, Mirsattari SM. Opioid-associated amnestic syndrome observed with fentanyl patch use. CMAJ 2019; 191:E337-E339.
4. Barash JA, Kofke WA. Connecting the dots: an association between opioids and acute hippocampal injury. Neurocase 2018; 24:124-131.
5. Barash JA, Whitledge J, Watson CJ, et al. Opioid-associated amnestic syndrome: description of the syndrome and validation of a proposed definition. J Neurol Sci 2020; 417:117048. 
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Related checklists

• Opioid encephalopathy: causes and classification
• Opioid leukoencephalopathy
• CHANTER syndrome
• Heroin toxicity
• Heroin spongiform leukoencephalopathy (HSLE)