Tongue fasciculations

Evidence-based neurology checklist on tongue fasciculations: Causes Motor neurone disease (MND) X-linked bulbospinal muscular atrophy (SBMA, Kennedy disease) Charcot Marie Tooth disease 4C (CMT4C) Anti NF155 chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) Spinocerebellar ataxia…

Causes

  • Motor neurone disease (MND)
  • X-linked bulbospinal muscular atrophy (SBMA, Kennedy disease)
  • Charcot Marie Tooth disease 4C (CMT4C)
  • Anti NF155 chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
  • Spinocerebellar ataxia type 3 (SCA3)
  • Spinocerebellar ataxia type 36 (SCA36)
  • Organophosphate poisoning
  • Myasthenia gravis (MG): especially anti MUSK
  • Osmotic demyelination disorder (ODD)
  • TTR familial amyloid neuropathy (FAP)
  • 4 Aminopyridine

Differentials

References

  1. Bertorini TE. Neuromuscular Case Studies. Butterworth Heinemann Philadelphia 2008 p 262.
  2. Leite MA, Orsini M, de Freitas MR, et al. Another perspective on fasciculations: when is it not caused by the classic form of amyotrophic lateral sclerosis or progressive spinal atrophy? Neurol Int 2014; 6:5208. 
  3. Colomer J, Gooding R, Angelicheva D, et al. Clinical spectrum of CMT4C disease in patients homozygous for the p.Arg1109X mutation in SH3TC2. Neuromuscul Disord 2006; 16:449-453.
  4. Salari M, Rezaei K, Mirdehghan A, Behzadi A, Etemadifar M. A review on approach to a twitchy tongue in neurology. Neurol Sci 2023; 44:2731-2741.
  5. Ikeda Y, Ohta Y, Kobayashi H, et al. Clinical features of SCA36: a novel spinocerebellar ataxia with motor neuron involvement (Asidan). Neurology 2012; 79:333-341.
  6. And 5 more. Subscribe to see the full list

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