Split hand syndrome

Evidence-based neurology checklist on split hand syndrome: Definition and mechanism This is disproportionate muscle wasting of the lateral half of the hand It is possibly due to cortical and spinal mechanisms It may be caused by more frequent use of the lateral hand muscles: pincer action and grip…

Definition and mechanism

  • This is disproportionate muscle wasting of the lateral half of the hand
  • It is possibly due to cortical and spinal mechanisms
  • It may be caused by more frequent use of the lateral hand muscles: pincer action and grip

Causes

Clinical features

Other split signs

Acronyms

References

  1. Eisen A, Kuwabara S. The split hand syndrome in amyotrophic lateral sclerosis. JNNP 2012; 83:399-403.
  2. Schelhaas HJ, van de Warrenburg BPC, Kremer HPH, Zwarts MJ. The "split hand" phenomenon: evidence of a spinal origin. Neurology 2003; 61:2619-1620.
  3. Kuwabara S, Sonoo M, Komori T, et al. Dissociated small hand muscle atrophy in amyotrophic lateral sclerosis: frequency, extent, and specificity. Muscle Nerve 2008; 37:426-430.
  4. Voermans NC, Schelhaas HJ, Munneke M, Zwarts MJ. Dissociated small hand muscle atrophy in aging: the 'senile hand' is a split hand. Eur J Neurol 2006; 13:1381-1384.
  5. Menon P, Bae JS, Mioshi E, Kiernan MC, Vucic S. Split-hand plus sign in ALS: differential involvement of the flexor pollicis longus and intrinsic hand muscles. Amyotroph Lateral Scler Frontotemporal Degener 2013; 14:315-318.
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