Thymoma associated multi-organ autoimmunity (TAMA)

Evidence-based neurology checklist on thymoma associated multi-organ autoimmunity (tama): Pathology This is a graft-versus-host-disease (GVHD) like disorder It results from the activation of autoreactive T cells in patients with thymoma It involves multiple organs Neurological features…

Pathology

  • This is a graft-versus-host-disease (GVHD) like disorder
  • It results from the activation of autoreactive T cells in patients with thymoma
  • It involves multiple organs

Neurological features

Haematological features

Dermatological features

Thyroid features

Immunological features

Anti-PIT-1 antibody syndrome

Other features

Treatment

References

  1. Evoli A, Minisci C, Di Schino C, et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002; 59:1844-1850.
  2. Suzuki S, Utsugisawa K, Suzuki N. Overlooked non-motor symptoms in myasthenia gravis. JNNP 2013; 84:989-994. 
  3. Bernard C, Frih H, Pasquet F, et al. Thymoma associated with autoimmune diseases: 85 cases and literature review. Autoimmun Rev 2016; 15:82-92.
  4. Mouyis M, Dollman G, Penn H, John L, Hamdulay S. Is it lupus? TAMA: an important multi-system autoimmune disease entity physicians need to consider. QJM 2016; 109:687-688.
  5. Tomaszek S, Wigle DA, Keshavjee S, Fischer S. Thymomas: review of current clinical practice. Ann Thorac Surg 2009; 87:1973-1980.
  6. And 10 more. Subscribe to see the full list

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