Myasthenia gravis (MG) with thymoma

Evidence-based neurology checklist on myasthenia gravis (mg) with thymoma: Pathology Thymomas are present in 15% of MG They are microscopic in 4% of cases: with diameter <1mm They are often invasive and cause severe myasthenia They are medullary, mixed, cortical, or well-differentiated carcinomas…

Pathology

  • Thymomas are present in 15% of MG
  • They are microscopic in 4% of cases: with diameter <1mm
  • They are often invasive and cause severe myasthenia
  • They are medullary, mixed, cortical, or well-differentiated carcinomas
  • The thymomas may be extra-thymic

Myasthenia gravis antibodies associated with thymoma

Features of MG associated with thymoma

Other neurological manifestations of thymoma

Other thymic pathologies associated with MG

References

  1. Evoli A, Minisci C, Di Schino C, et al. Thymoma in patients with MG: characteristics and long-term outcome. Neurology 2002; 59:1844-1850.
  2. Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2010; 17:893-902.
  3. Vaideeswar P. Microscopic thymoma: a report of four cases with review of literature. Indian J Pathol Microbiol 2011; 54:539-541. 
  4. Chalabreysse L, Orsini A, Vial C, Tronc F. Microscopic thymoma. Interact Cardiovasc Thorac Surg 2007; 6:133-135. 
  5. Fukuhara M, Higuchi M, Owada Y, et al. Clinical and pathological aspects of microscopic thymoma with myasthenia gravis and review of published reports. J Thorac Dis 2017; 9:1592-1597.
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