Thrombolysis: indications
Evidence-based neurology checklist on thrombolysis: indications: Time indication Administration within 4.5 hours of stroke onset It may be safe and effective up to 9 hours after stroke onset Size indication Conditional indications: wake up stroke Conditional indications: others
Time indication
- Administration within 4.5 hours of stroke onset
- It may be safe and effective up to 9 hours after stroke onset
Size indication
Conditional indications: wake up stroke
Conditional indications: others
References
- Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359:1317-1329.
- Altersberger VL, Sibolt G, Enz LS, et al. Intravenous thrombolysis 4.5-9 hours after stroke onset: a cohort study from the TRISP collaboration. Ann Neurol 2023 (Online ahead of print).
- Riedel CH, Zimmermann P, Jensen-Kondering U, et al. The importance of size: successful thrombolysis in acute anterior stroke depends on thrombus length. Stroke 2011; 42:1775-1777.
- Kvistad CE, Novotny V, Kurz MW, et al. Safety and outcomes of tenecteplase in moderate and severe ischemic stroke. Stroke 2019; 50:1279-1281.
- Berge E, Whiteley W, Audebert H, et al. European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur Stroke J 2021; 6:I-LXII.
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