Thrombolysis: bleeding risk factors

Evidence-based neurology checklist on thrombolysis: bleeding risk factors: Individual risk factors Male gender Obesity Possibly older age Cardiovascular risk factors Anti-thrombotic risk factors Medical risk factors

Individual risk factors

  • Male gender
  • Obesity
  • Possibly older age

Cardiovascular risk factors

Anti-thrombotic risk factors

Medical risk factors

References

  1. Miller DJ, Simpson JR, Silver B. Safety of thrombolysis in acute ischemic stroke: a review of complications, risk factors, and newer technologies. Neurohospitalist 2011; 1:138-147.
  2. Meseguer E, Labreuche J, Olivot JM, et al. Determinants of outcome and safety of intravenous rt-PA therapy in the very old: a clinical registry study and systematic review. Age Aging 2008; 37:107-111.
  3. Berrouschot J, Rother J, Glahn J, Kucinski T, Fiehler J, Thomalla G. Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (>=80 years) stroke patients. Stroke 2005; 36:2421-2425.
  4. Mateen FJ, Buchan AM, Hill MD. Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus nonagenarians. Stroke 2010; 41:1833-1835.
  5. Mishra NK, Diener H-C, Lyden PD, et al. Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA). Stroke 2010; 41:2840-2848.
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