Stroke stem cell therapy

Evidence-based neurology checklist on stroke stem cell therapy: Background This is an investigational treatment for stroke It has regenerative potential Agents Routes of administration Benefits and risks

Background

  • This is an investigational treatment for stroke
  • It has regenerative potential

Agents

Routes of administration

Benefits and risks

References

  1. Kalladka D, Sinden J, Pollock K, et al. Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet 2016; 388:787-796. 
  2. Hess DC, Wechsler LR, Clark WM, et al. Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 2017; 16:360-368. 
  3. Marei HE, Hasan A, Rizzi R, et al. Potential of stem cell-based therapy for ischemic stroke. Front Neurol 2018; 9:34. 
  4. Dulamea AO. The potential use of mesenchymal stem cells in stroke therapy-from bench to bedside. J Neurol Sci 2015; 352:1-11.
  5. Chung JW, Chang WH, Bang OY, et al. Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke. Neurology 2021; 96:e1012-e1023.
  6. And 6 more. Subscribe to see the full list

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