Spastic paraparesis: treatment

Evidence-based neurology checklist on spastic paraparesis: treatment: Main drugs Baclofen oral: 5-20mg tid or qid Clonazepam: 0.5-1mg daily Dantrolene: 25-100mg qid Diazepam: 5-20mg tid Gabapentin: 240-360mg daily Tizanidine: 4-36mg daily Main interventional treatments Other drugs Other treatments

Main drugs

  • Baclofen oral: 5-20mg tid or qid
  • Clonazepam: 0.5-1mg daily
  • Dantrolene: 25-100mg qid
  • Diazepam: 5-20mg tid
  • Gabapentin: 240-360mg daily
  • Tizanidine: 4-36mg daily

Main interventional treatments

Other drugs

Other treatments

References

  1. Thibaut A, Chatelle C, Ziegler E, Bruno MA, Laureys S, Gosseries O. Spasticity after stroke: physiology, assessment and treatment. Brain Inj 2013; 27:1093-1105. 
  2. Chang E, Ghosh N, Yanni D, Lee S, Alexandru D, Mozaffar T. A review of spasticity treatments: pharmacological and interventional approaches. Crit Rev Phys Rehabil Med 2013; 25:11-22.
  3. Peck J, Urits I, Kassem H, et al. Interventional approaches to pain and spasticity related to cerebral palsy. Psychopharmacol Bull 2020; 50(4 Suppl 1):108-120.

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