Refractory status epilepticus (RSE): treatment

Thiopentone

• The dose is 3-5mg/kg bolus
• Then 1-2mg/kg every 2-3 minutes until seizure control

Midazolam

Propofol

Emerging treatments: Ketamine

Emerging treatments: others

Treatment options for refractory complex partial status epilepticus

Immunotherapy for NORSE

Goal of treatment

Complications of treatments

Acronym

References

1. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain 2011; 134:2802-2818.
2. Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofol infusion syndrome: a structured literature review and analysis of published case reports. Br J Anaesth 2019; 122:448-459. 
3. López N, Correa A, Ammann R, Diettes A, Riveros R, Torres F. Propofol infusion syndrome in a refractory epileptic status case. Rev Chil Pediatr 2018; 89:384-390.
4. Krajčová A, Waldauf P, Anděl M, Duška F. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care 2015; 19:398.
5. Mirrakhimov AE, Voore P, Halytskyy O, Khan M, Ali AM. Propofol infusion syndrome in adults: a clinical update. Crit Care Res Pract 2015; 2015:260385.
6. And 16 more. Subscribe to see the full list

Related checklists

• Refractory status epilepticus (RSE): classification
• Now onset refractory status epilepticus (NORSE)
• Febrile infection-related epilepsy syndrome (FIRES)
• Super refractory status epilepticus (SRSE)
• Refractory status epilepticus (RSE): investigations