POEMS syndrome: treatment

Evidence-based neurology checklist on poems syndrome: treatment: Standard treatments Radiotherapy Systemic chemotherapy Autologous stem cell transplant Chelating agents and steroids Chemotherapy followed by peripheral blood stem cell transplant Rituximab Bevacizumab (anti VEGF): this reportedly…

Standard treatments

  • Radiotherapy
  • Systemic chemotherapy
  • Autologous stem cell transplant
  • Chelating agents and steroids
  • Chemotherapy followed by peripheral blood stem cell transplant
  • Rituximab
  • Bevacizumab (anti VEGF): this reportedly results in a poor response

Emerging treatments

Poorly effective or ineffective treatments

Acronym

Synonym

References

  1. Joint Task Force of the EFNS and the PNS. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinaemic demyelinating neuropathies. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. J Peripher Nerve Syst 2006; 11:9-19.
  2. So YT. Immune-mediated neuropathies. Continuum (Minneap Minn) 2012; 18:85-105.
  3. Sekiguchi Y, Misawa S, Shibuya K, et al. Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome. JNNP 2013; 84:1346-1348.
  4. Misawa S, Sato Y, Katayama K, et al; Japanese POEMS Syndrome for Thalidomide (J-POST) Trial Study Group. Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol 2016; 15:1129-1137.
  5. Royer B, Merlusca L, Abraham J, et al. Efficacy of lenalidomide in POEMS syndrome: a retrospective study of 20 patients. Am J Hematol 2013; 88:207-212. 
  6. And 1 more. Subscribe to see the full list

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