POEMS syndrome: clinical features
Evidence-based neurology checklist on poems syndrome: clinical features: Polyneuropathy This is a subacute progressive sensorimotor neuropathy It is a length-dependent mixed axonal and demyelinating neuropathy The onset is often with positive symptoms before progressive weakness Only half of cases…
Polyneuropathy
- This is a subacute progressive sensorimotor neuropathy
- It is a length-dependent mixed axonal and demyelinating neuropathy
- The onset is often with positive symptoms before progressive weakness
- Only half of cases start with neuropathy
Organ involvement
Endocrine features
M protein
Skin lesions
Other features
Proposed major diagnostic criteria
Proposed minor diagnostic criteria (≥2 required)
Poor prognostic features
Acronyms
Synonym
References
- So YT. Immune-mediated neuropathies. Continuum (Minneap Minn) 2012; 18:85-105.
- Mauerman ML, Sorenson EJ, Dispenzieri A, et al. Uniform demyelination and more severe axonal loss distinguish POEMS syndrome from CIDP. JNNP 2012; 83:480-486.
- Arimura K. Early recognition of POEMS syndrome: what is the role of neurophysiology? JNNP 2012; 83:474.
- Riccio A, Natale D, Pettinato G, Sparano L, Petto A, Puzziello A. Castleman's disease. Ann Rheum Dis 2001; 60:176.
- Naddaf E, Dispenzieri A, Mandrekar J, Mauermann ML. Clinical spectrum of Castleman disease-associated neuropathy. Neurology 2016; 87:2457-2462.
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