Myotonic dystrophy type 1: treatments

Evidence-based neurology checklist on myotonic dystrophy type 1: treatments: Myotonia Mexiletene Phenytoin Procainamide Tricyclics Benzodiazepine Heated gloves Fatigue and daytime sleepiness Arrhythmias Cardiomyopathy Ophthalmic disorders Gastrointestinal disorders Respiratory dysfunction…

Myotonia

  • Mexiletene
  • Phenytoin
  • Procainamide
  • Tricyclics
  • Benzodiazepine
  • Heated gloves

Fatigue and daytime sleepiness

Arrhythmias

Cardiomyopathy

Ophthalmic disorders

Gastrointestinal disorders

Respiratory dysfunction

Vaccinations

Investigational treatments

References

  1. Turner C, Hilton-Jones D. The myotonic dystrophies: diagnosis and management. JNNP 2010; 81:358-367.
  2. Longman C. Myotonic dystrophy. J R Coll Physicians Edin 2006; 36:51-55.
  3. Ashizawa T, Gagnon C, Groh WJ, et al. Consensus-based care recommendations for adults with myotonic dystrophy type 1. Neurol Clin Pract 2018; 8:507-520.
  4. Logigian EL, Martens WB, Moxley RT 4th, et al. Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1. Neurology 2010; 74:1441-1448.
  5. Heatwole C, Luebbe E, Rosero S, et al. Mexiletine in myotonic dystrophy type 1: a randomized, double-blind, placebo-controlled trial. Neurology 2021; 96:e228-e240. 
  6. And 7 more. Subscribe to see the full list

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