Migraine: non-modifiable risk factors

Evidence-based neurology checklist on migraine: non-modifiable risk factors: Individual risk factors Caucasian ethnicity Male sex: this is a risk factor for migraine starting before puberty Female sex: this is a risk factor for migraine starting after puberty Early puberty Excessive female…

Individual risk factors

  • Caucasian ethnicity
  • Male sex: this is a risk factor for migraine starting before puberty
  • Female sex: this is a risk factor for migraine starting after puberty
  • Early puberty
  • Excessive female hormones in males
  • Family history of migraine

Familial hemiplegic migraine (FMH) gene mutations

High homocysteine gene mutations

Other genetic risk factors

Hypercoagulable risk factors

Other non-modifiable risk factors

Protective factors

Acronyms

References

  1. Lipton RB, Bigal ME. Migraine: epidemiology, impact, and risk factors for progression. Headache 2005; (45 Suppl 1):S3-S13.
  2. Pakalnis A. Migraine and hormones. Semin Pediatr Neurol 2016; 23:92-94. Stewart WF, Roy J, Lipton RB. Migraine prevalence, socioeconomic status, and social causation. Neurology 2013; 81:948-955.
  3. Bond DS, Roth J, Nash JM, Wing RR. Migraine and obesity: epidemiology, possible mechanisms and the potential role of weight loss treatment. Obes Rev 2011; 12:e362-371.
  4. van Oosterhout WPJ, Schoonman GG, van Zwet EW, et al. Female sex hormones in men with migraine. Neurology 2018; 91:e374-e381.
  5. Russell MB, Olesen J. Increased familial risk and evidence of genetic factor in migraine. BMJ 1995; 311:541-544.
  6. And 18 more. Subscribe to see the full list

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