Macrophagic myofasciitis (MMF)
Evidence-based neurology checklist on macrophagic myofasciitis (mmf): Pathology This is a granulomatous inflammatory myopathy in reaction to intramuscular vaccines The vaccines contain aluminium hydroxide adjuvants There may be a genetic susceptibility with HLA-DRB1*01 It has been reported with…
Pathology
- This is a granulomatous inflammatory myopathy in reaction to intramuscular vaccines
- The vaccines contain aluminium hydroxide adjuvants
- There may be a genetic susceptibility with HLA-DRB1*01
- It has been reported with HBV, HAV, and tetanus vaccines
- The median interval to symptom onset is 7 months: the range is 2 weeks to 8 years
- Some cases are not related to vaccination
Demographic features
Other autoimmune syndromes induced by adjuvants (ASIA)
Muscle features
Cognitive features
Other neurological features
Systemic features
Associated autoimmune diseases
Differential diagnosis
Muscle biopsy
Other investigations
Treatment
Synonym
References
- Lach B, Cupler EJ. Macrophagic myofasciitis in children is a localized reaction to vaccination. J Child Neurol 2008; 23:614-619.
- Rivas E, Gómez-Arnáiz M, Ricoy JR, et al. Macrophagic myofasciitis in childhood: a controversial entity. Pediatr Neurol 2005; 33:350-356.
- Nevo Y, Kutai M, Jossiphov J, et al. Childhood macrophagic myofasciitis-consanguinity and clinicopathological features. Neuromuscul Disord 2004; 14:246-252.
- Gherardi RK, Coquet M, Cherin P, et al. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle. Brain 2001; 124:1821-1831.
- Authier FJ, Cherin P, Creange A, et al. Central nervous system disease in patients with macrophagic myofasciitis. Brain 2001; 124:974-983.
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