Ipilimumab toxicity

Evidence-based neurology checklist on ipilimumab toxicity: Neurological features Myositis Polyradiculopathy Guillain Barre syndrome (GBS) Vasculitic neuropathy Non-neurological features

Neurological features

  • Myositis
  • Polyradiculopathy
  • Guillain Barre syndrome (GBS)
  • Vasculitic neuropathy

Non-neurological features

References

  1. Touat M, Maisonobe T, Knauss S, et al. Immune checkpoint inhibitor-related myositis and myocarditis in patients with cancer. Neurology 2018; 91:e985-e994.
  2. Shah M, Tayar JH, Abdel-Wahab N, Suarez-Almazor ME. Myositis as an adverse event of immune checkpoint blockade for cancer therapy. Semin Arthritis Rheum 2018; doi: 10.1016/j.semarthrit.2018.05.006 (Epub ahead of print).
  3. Manousakis G, Koch J, Sommerville RB, et al. Multifocal radiculoneuropathy during ipilimumab treatment of melanoma. Muscle Nerve 2013; 48:440-444.
  4. Supakornnumporn S, Katirji B. Guillain-Barré syndrome triggered by immune checkpoint inhibitors: a case report and literature review. J Clin Neuromuscul Dis 2017; 19:80-83.
  5. Hwang SJ, Carlos G, Wakade D, Sharma R, Fernandez-Penas P. Ipilimumab-induced acute generalized exanthematous pustulosis in a patient with metastatic melanoma. Melanoma Res 2016; 26:417-420.
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