Immune checkpoint inhibitors (ICI): toxicity management

Evidence-based neurology checklist on immune checkpoint inhibitors (ici): toxicity management: Autoimmune tests NMDAR Caspr1 Anti-MOG Anti-NMO Paraneoplastic Anti AChR Anti-MUSK Anti-ganglioside Myositis panel Other blood tests Other investigations Treatment

Autoimmune tests

  • NMDAR
  • Caspr1
  • Anti-MOG
  • Anti-NMO
  • Paraneoplastic
  • Anti AChR
  • Anti-MUSK
  • Anti-ganglioside
  • Myositis panel

Other blood tests

Other investigations

Treatment

References

  1. Spain L, Tippu Z, Larkin JM, Carr A, Turajlic S. How we treat neurological toxicity from immune checkpoint inhibitors. ESMO Open 2019; 4(Suppl 4):e000540.
  2. Astaras C, de Micheli R, Moura B, Hundsberger T, Hottinger AF. Neurological adverse events associated with immune checkpoint inhibitors: diagnosis and management. Curr Neurol Neurosci Rep 2018; 18:3.
  3. Thummalapalli R, Sena LA, Probasco JC, Gladstone DE. Checkpoint inhibitor-induced autoimmune encephalitis reversed by rituximab after allogeneic bone marrow transplant in a patient with Hodgkin lymphoma. Leuk Lymphoma 2020; 61:228-230.

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