Hereditary spastic paraplegia type 70 (SPG70)

Evidence-based neurology checklist on hereditary spastic paraplegia type 70 (spg70): Genetics This is caused by mutations in the MARS gene on chromosome 12q The transmission is autosomal recessive The onset age is 6 months Clinical features

Genetics

  • This is caused by mutations in the MARS gene on chromosome 12q
  • The transmission is autosomal recessive
  • The onset age is 6 months

Clinical features

References

  1. Novarino G, Fenstermaker AG, Zaki MS, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science 2014; 343:506-511. 

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