Dopamine agonists
Evidence-based neurology checklist on dopamine agonists: Types and doses Pramipexole PO: 0.125mg tid titrated weekly to 0.25-1.5mg tid Ropinirole PO: 0.25mg tid titrated weekly to a maximum of 24mg daily Rotigotine patch: 2mg over 24 hours titrated weekly to maximum of 8mg over 24 hours…
Types and doses
- Pramipexole PO: 0.125mg tid titrated weekly to 0.25-1.5mg tid
- Ropinirole PO: 0.25mg tid titrated weekly to a maximum of 24mg daily
- Rotigotine patch: 2mg over 24 hours titrated weekly to maximum of 8mg over 24 hours
- Pramipexole and Ropinirole have crushed immediate-release formulations
Indications
Contraindications as initial therapy
Monitoring indices
Systemic side effects
Neurological side effects
References
- DeMaagd G, Philip A. Part 2: Introduction to the pharmacotherapy of Parkinson's disease, with a focus on the use of dopaminergic agents. P T 2015; 40:590-600.
- Alty J, Robson J, Duggan-Carter P, Jamieson S. What to do when people with Parkinson's disease cannot take their usual oral medications. Pract Neurol 2016; 16:122-128.
- Oertel W, Schulz JB. Current and experimental treatments of Parkinson disease: A guide for neuroscientists. J Neurochem 2016; 139(Suppl 1):325-337.
- Pringsheim T, Day GS, Smith DB, et al. Dopaminergic therapy for motor symptoms in early Parkinson disease practice guideline summary: a report of the AAN Guideline Subcommittee. Neurology 2021; 97:942-957.
