Catechol O methyltransferase (COMT) inhibitors
Evidence-based neurology checklist on catechol o methyltransferase (comt) inhibitors: Types and doses Entacapone: 200mg added to each dose of Levodopa Opicapone: 50mg daily Tolcapone: 100-200mg tid Indications Precautions Systemic side effects Neurological side effects
Types and doses
- Entacapone: 200mg added to each dose of Levodopa
- Opicapone: 50mg daily
- Tolcapone: 100-200mg tid
Indications
Precautions
Systemic side effects
Neurological side effects
References
- Holm KJ, Spencer CM. Entacapone. A review of its use in Parkinson's disease. Drugs 1999; 58:159-177.
- Lees AJ, Ferreira J, Rascol O, et al; BIPARK-2 Study Investigators. Opicapone as adjunct to levodopa therapy in patients with parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol 2017; 74:197-206.
- Lees AJ, Ferreira J, Rascol O, et al; BIPARK-2 Study Investigators. Opicapone as adjunct to levodopa therapy in patients with parkinson disease and motor fluctuations: a randomized clinical trial. JAMA Neurol 2017; 74:197-206.
- Ferreira JJ, Lees A, Rocha JF, et al; Bi-Park 1 investigators. Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial. Lancet Neurol 2016; 15:154-165.
- Fabbri M, Rosa MM, Ferreira JJ. Clinical pharmacology review of opicapone for the treatment of Parkinson's disease. Neurodegener Dis Manag 2016; 6:349-362.
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