Dementia with Lewy bodies (DLB): neurological treatments

Evidence-based neurology checklist on dementia with lewy bodies (dlb): neurological treatments: Levodopa A third of cases demonstrate Levodopa-responsiveness Younger patients are more likely to respond Treatment of cognitive impairment Treatment of visual hallucinations Treatment of behavioural…

Levodopa

  • A third of cases demonstrate Levodopa-responsiveness
  • Younger patients are more likely to respond

Treatment of cognitive impairment

Treatment of visual hallucinations

Treatment of behavioural symptoms

Treatment of REM sleep behaviour disorder (RBD)

Treatment of excessive daytime sleepiness (EDS)

Drugs to avoid

References

  1. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996; 47:1113-1124.
  2. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology 2005; 65:1863-1872.
  3. Hanagasi HA, Bilgiç B, Emre M. Neuroimaging, biomarkers, and management of dementia with Lewy bodies. Front Neurol 2013; 4:151.
  4. Taylor JP, McKeith IG, Burn DJ, et al. New evidence on the management of Lewy body dementia. Lancet Neurol 2020; 19:157-169.
  5. Molloy S, McKeith IG, O'Brien JT, Burn DJ. The role of levodopa in the management of dementia with Lewy bodies. JNNP 2005; 76:1200-1203.
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