Dementia with Lewy bodies (DLB): investigations

Evidence-based neurology checklist on dementia with lewy bodies (dlb): investigations: Indicative biomarkers Dopamine transporter (DaT) scan MIBG myocardial scintigraphy Polysomnography Magnetic resonance imaging (MRI) brain: atrophic areas Magnetic resonance imaging (MRI) brain: loss of swallow…

Indicative biomarkers

  • Dopamine transporter (DaT) scan
  • MIBG myocardial scintigraphy
  • Polysomnography

Magnetic resonance imaging (MRI) brain: atrophic areas

Magnetic resonance imaging (MRI) brain: loss of swallow tail sign

Diffusion tensor imaging (DTI): increased diffusion areas

Single photon emission and positron emission tomography (FP-CIT SPECT)

Electroencephalogram (EEG): features

Other investigations

Emerging investigations

References

  1. McKeith IG, Boeve BF, Dickson DW, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 2017; 89:88-100. 
  2. Hanagasi HA, Bilgiç B, Emre M. Neuroimaging, biomarkers, and management of dementia with Lewy bodies. Front Neurol 2013; 4:151.
  3. Outeiro TF, Koss DJ, Erskine D, et al. Dementia with Lewy bodies: an update and outlook. Mol Neurodegener 2019; 14:5.
  4. Shams S, Fällmar D, Schwarz S, et al. MRI of the swallow tail sign: a useful marker in the diagnosis of Lewy body dementia? Am J Neuroradiol 2017; 38:1737-1741.
  5. Schwarz ST, Afzal M, Morgan PS, Bajaj N, Gowland PA, Auer DP. The 'swallow tail' appearance of the healthy nigrosome - a new accurate test of Parkinson's disease: a case-control and retrospective cross-sectional MRI study at 3T. PLoS One. 2014; 9:e93814.
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